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Objective: The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. Methods: Eighty-six postmenopausal and 51 bilaterally ovariectomized women who had been suffering from vasomotor symptoms such as hot flush or atrophy...
Background: The role of hormone-replacement therapy in decreasing the risk of cardiovascular disease in women has not been firmly established. Recent studies have shown that the selective estrogen receptor modulators raloxifene, and tamoxifene, posses hypolipidemic and antiatherogenic properties. Methods and results: Forty-three adult female rabbits were submitted to ovariectomy (moment 1). Three...
Objective: To evaluate the effect of transdermal estradiol therapy (ET) on coagulation and fibrinolysis markers in postmenopausal women. Methods: Prospective open trial study in 59 healthy hysterectomized postmenopausal women. Thirty women received transdermal ET (50μg per day) during 3 months and 29 women formed the untreated arm. Results: Baseline factor VII-tissue factor complex (VIIa-rTF), fibrinogen...
Objective: Although a close relationship between the oral discomfort and the menopause is suggested, it is not clear if the alteration of sex steroids would cause any histological or even pathological change in the oral mucosa. The aim of this study was to investigate the possible effect of sex steroid deficiency on the rat oral mucosa as well as the effect of its replacement. Methods: The oral mucosa...
Objective: To investigate how risks and benefits of hormone replacement therapy (HRT) are communicated to women in clinical practice. To evaluate the usefulness of a risk classification based on context framing, i.e. whether the risk is discussed for one or several alternative treatments, and/or in the same context as possible benefits. Design: Analysis of structure and content of transcribed consultations...
Osteoporosis represents a major public health problem by virtue of later life association with fragility fractures which may indeed be the first sign of this “silent epidemic”. While as prevalent as cardiovascular and other age-related chronic diseases, efforts at osteoporosis prevention have been less successful due to limited commitment among the public to take steps to maintain their “bone health”,...
Objective: To search and compare the effects of three different HRT regimens on nitric oxide levels of postmenopausal women.Methods: Four groups of postmenopausal women were included in this prospective, randomised, placebo controlled study. 34 women used 0.625mg conjugated estrogen continuously combined with 5mg medroxyprogesterone acetate, 32 women used 2.5mg tibolone, 26 women used 50mcg transdermal...
Objectives: The aim of this study was to determine the prevalence, awareness and determinants of urinary incontinence (UI) among Qatari women and the sociodemographic factors involved in their health care-seeking behaviour.Design: A cross-sectional study was used to determine the symptoms of UI experienced by Arabian Gulf women.Setting: Primary Health Care (PHC) Centres and community-based study in...
Background: When genital atrophy exists, systemic hormone therapy (HT) has a timing until to induce vaginal proliferation and symptomatic relieve. Thus, in order to obtain a prompt improvement, the association of local therapy acting on the genital epithelium to the systemic treatment should be considered. Objective: To evaluate the effects of a combined therapy consisting of vaginal estriol with...
Atrophic-erosive lichen planus with oral and genital involvement is a rare condition and is often difficult to diagnose. Patients seldom report genital symptoms to the dentist and dentists do not generally investigate about genital lesions. Delays in diagnosis may cause complications and affect the quality of life. We report the clinical and histopathological features of two new cases of oro-vaginal-vulvar...
Objective: To compare the diagnostic accuracy of ultrasonographic endometrial thickness and outpatient hysteroscopy, to establish the most appropriate exam for the diagnosis of endometrial cancer in postmenopausal women with abnormal uterine bleeding (AUB). The secondary aim was to develop a multivariable approach considering clinical history as an added value for these diagnostic procedures. Methods:...
Sleep disturbances in peri- and postmenopausal women may result from hormonal changes, vasomotor symptoms, and possibly psychological factors. Hormone replacement therapy (HRT) seems to diminish the disruption of sleep in climacteric women. The aim of this study was to determine the effects of a low dose of conjugated equine estrogens (CE) in combination with different progestins (LD-HRT) and evaluate...
Objectives: Prevalence studies show that nocturia is a very common condition, affecting older age groups in particular. In this study, we evaluate (1) the community-based prevalence of nocturia and its associated overactive bladder according to the patient's perception and disturbance to sleep and (2) whether age or menopausal (MP) transition has a greater effect on the occurrence of nocturia. Methods:...
Objective: To analyse the relationship between oral dryness (OD), nocturia, the menopausal transition and some medical conditions and medications in women. Methods: A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jamtland, Sweden. Questions were asked about occurrence of somatic diseases and symptoms, nocturia, nocturnal thirst and drinking,...
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